Table 2.

Allele and genotype frequencies of MIF -794 CATT_5–8 and -173 G/C SNP for Caucasian patients with AIH and PBC compared to healthy Caucasian controls. The adjusted p values were calculated by permutation testing to account for multiple comparisons.

	Healthy Controls %	AIH %	PBC %
-794 CATT5–8	(N=286)	(N=41)	(N=262)
5	23.8	26.1	31.1*
6	63.6	51.1	61.5
7	11.9	20.5‡	7.3†
8	0.7	2.3	0.2
55	9.8	13.6	16.4§
56	23.4	22.7	24.8
57	4.2	2.3	4.6
58	0.3	0	0
66	45.5	31.8	45.4
67	12.6	13.6	6.9
68	0.3	2.3	0.4
77	3.5	11.4||,¶	1.5
78	0	2.3	0
88	0.3	0	0
-173 C/G	(N=286)	(N=45)	(N=304)
C	12.4	15.6	15.8
G	87.6	84.4	84.2
CC	1.4	2.2	2.3
CG	22.0	28.8	27.0
GG	76.6	69.0	70.7

1. Allele:

AIH or PBC vs. Healthy controls:

• CATT₅
• *PBC vs. Healthy controls [OR 1.34, CI 1.05–1.7, p=0.0165, adjusted p=0.0331]
• CATT₇
• AIH vs. Healthy controls [OR 1.68, CI 1.0–2.84, p=0.051, adjusted p=0.114]
• ^†PBC vs. Healthy controls [OR = 0.63, CI 0.43–0.93, p=0.0188, adjusted p=0.0389].

AIH vs. PBC:

• CATT₅
• AIH vs. PBC [p = 0.627, adjusted p=0.899]
• CATT₇
• ^‡AIH vs. PBC [p=0.00102, adjusted p=0.0013].

2. Genotype:

AIH or PBC vs. Healthy control:

• CATT₅₅
• ^§PBC vs. Healthy controls [OR 1.81, CI 1.09–3.01, p=0.022, adjusted p=0.099]
• CATT₇₇
• ^||AIH vs. Healthy controls [OR 3.83, CI 1.24–11.85, p=0.0196, adjusted p=0.0704]
• PBC vs. Healthy controls [OR 0.43, CI 0.13–1.38, p=0.156, adjusted p=0.639].

AIH vs. PBC:

• CATT₅₅
• AIH vs. PBC [p=0.774]
• CATT₇₇
• ^¶AIH vs. PBC [p=0.00158, adjusted p=0.0074].