Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Agonist stimulation, signaling via G protein coupled receptors (GPCRs) and/or growth factor receptors can lead to “inside-out” signaling of integrins. Extracellular domains of resting integrins open up to bind extracellular matrix ligands (L). This leads to “outside-in” signaling of integrins resulting in cytoskeletal remodeling and downstream signaling cascades.
