TABLE 3.
Summary of histopathological evaluation of brain and spinal cord in monkeys inoculated by the i.c. route with tetravalent ChimeriVax-DEN vaccine or YF-VAX
| Treatment group | No. of monkey | Lesion scores (mean ± SD)
|
||
|---|---|---|---|---|
| Target areas | Discriminator areas | Combined | ||
| YF-VAX® | 11 | 0.43 ± 0.36 | 0.35 ± 0.32 | 0.39 ± 0.32 |
| Tetravalent ChimeriVax-DEN | 11 | 0.05 ± 0.08 | 0.03 ± 0.06 | 0.04 ± 0.05 |
| P valuea | 0.0023 | 0.0015 | 0.0018 | |
a
Nonparametric Wilcoxon/Kruskal-Wallis test (rank sums) was used for statistical comparison of groups.