Figure 1. Overview of the proposed framework to construct miRNA-protein complex modules and calculate module entropy between cancer and normal states.

Protein complexes and miRNAs are integrated to construct modules (X) from gene and miRNA expression data. The modules represent the mutual information between the expression of miRNAs and protein in the module. SVD is applied to decompose modules' matrix and Shannon entropy is calculated for each module in normal and cancer. The last step is to find modules with significant difference between normal and cancer entropy.