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. 2013 Dec 31;8(12):e84530. doi: 10.1371/journal.pone.0084530

Table 5. Pharmacokinetic parameters of scutellarin orally dosed in various formulations (40 mg/kg equivalent to scutellarin) to SD rats (n = 5).

Formulations Cmax (ng/mL) Tmax (h) T1/2z (h) AUC(0-t) (ng·h/mL)
Scutellarin powder 178±35 5.2±0.8 34.8±22.8 2673.5±404.1
SPC 198±41 4.2±0.8* 22.6±8.2 3374.9±573.2
Conventional SEDDS 290±39* # 0.6±0.2**## 25.9±9.2 4192.5±903.8*
Super-SEDDS 334±49**## 0.5**## 26.0±15.7 4612.4±631.1**#

Data represents mean ± SD, n = 5.

p<0.05 and **p<0.001 compared with scutellarin powder.

# p<0.05 and ## p<0.001 compared with SPC.