Table 5. Pharmacokinetic parameters of scutellarin orally dosed in various formulations (40 mg/kg equivalent to scutellarin) to SD rats (n = 5).
Formulations | Cmax (ng/mL) | Tmax (h) | T1/2z (h) | AUC(0-t) (ng·h/mL) |
Scutellarin powder | 178±35 | 5.2±0.8 | 34.8±22.8 | 2673.5±404.1 |
SPC | 198±41 | 4.2±0.8* | 22.6±8.2 | 3374.9±573.2 |
Conventional SEDDS | 290±39* # | 0.6±0.2**## | 25.9±9.2 | 4192.5±903.8* |
Super-SEDDS | 334±49**## | 0.5**## | 26.0±15.7 | 4612.4±631.1**# |
Data represents mean ± SD, n = 5.
p<0.05 and **p<0.001 compared with scutellarin powder.
# p<0.05 and ## p<0.001 compared with SPC.