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. 2013 Dec 31;8(12):e84398. doi: 10.1371/journal.pone.0084398

Figure 4. Structural context of subfamily-specific conserved sites.

Figure 4

Subfamily-specific conserved positions are shown in green and space-filling on their respective crystallographic or modeled structures. The DNA operator (yellow) is shown bound to CcpA and PurR; an allosteric effector is shown bound to PurR (purple spacefilling); phosphorylated HPr (purple ribbon) is shown bound to CcpA. Allosteric effector binding in the cleft between N- and C-regulatory subdomains is common to all six subfamilies, while HPr-Ser46-P interacts only with CcpA. Molecular graphics were created in UCSF Chimera 1.6.2 [33].