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. 2013 Dec 31;8(12):e84340. doi: 10.1371/journal.pone.0084340

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© 2013 Jin et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

PMC Copyright notice

A. Mice were genotyped for the Mcp-2 gene variant by allele-specific PCR and the Mcp-4 gene variant by restriction fragment length polymorphism (RFLP) with NdeI. BMMCs derived from these mice were analyzed for Mcp-2 and Mcp-4 protein expressions by Commassie blue staining and western blotting. B. BMMCs from B6 and B6-cma mice were analyzed for chymase activity. In at least 45 mice analyzed, there is a perfect correlation of Mcp-2 and Mcp-4 gene variants with overexpression of Mcp-2 and Mcp-4 and increased chymase activity.