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. 2013 Dec 31;8(12):e85147. doi: 10.1371/journal.pone.0085147

Figure 4. Pericytes and Flt-3L enhance the ability of SCF, IL-3, SDF-1α and FGF-2 to stimulate EC tubulogenesis in 3D fibrin matrices.

Figure 4

ECs were seeded with or without pericytes and hematopoietic stem cell cytokines (SCF, IL-3, SDF-1α, FGF-2) were added into the fibrin matrices in the presence or absence of Flt-3L. After 72 hr, cultures were fixed, photographed (B), and quantitated for EC tube formation using Metamorph Software (A). Asterisks indicate significance at p< .01 with respect to the EC only cultures, while the triangles indicate significance at p< .01 with respect to cultures without Flt-3L addition (n=20, values are averaged + SD). Bar equals 25 µm.