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. 2013 Dec 31;8(12):e85046. doi: 10.1371/journal.pone.0085046

Figure 8. Proposed mechanism for rhSP-D mediated apoptosis in AML14.3D10 eosinophilic leukemic cells.

Figure 8

rhSP-D leads to oxidative stress and reduction in the levels of HMGA1. This possibly results in phosphorylation of p53 (Ser15) and Cdc2 (Tyr15). p21 levels were also found to be upregulated. p21 elevation and Cdc2 phosphorylation contribute to Cdc2 inhibition leading to G2/M arrest. Taken together, these overall changes lead to G2/M arrest followed by apoptosis. The superscripts (1-9) are the changes observed during the study.