Table 5. Genotype Frequencies of PARP1 Gene Polymorphism in Breast Cancer Cases HER positive and HER negative.
| Genotype | Case Parameter | Control | OR | 95% CI | Χ2 | p- value |
|---|---|---|---|---|---|---|
| ER+ve | ||||||
| Val/Val (wild) | 34 (0.64) | 75 (0.78) | Ref | |||
| Val/Ala | 14 (0.26) | 20 (0.21) | 1.544 | 0.698-3.416 | 1.16 | 0.28179 |
| Ala/Ala (variant) | 5 (0.10) | 1 (0.01) | 11.029 | 1.24-98.05 | 6.90 | 0.00863 |
| Val/Ala + Ala/Ala | 19 (.36) | 21 (0.22) | 1.996 | 0.951-4.188 | 3.40 | 0.06538 |
| Val | 82 (0.77) | 206 (0.89) | Ref | |||
| Ala | 24 (0.23) | 22 (0.11) | 2.262 | 1.198-4.271 | 6.54 | 0.01053 |
| ER -ve | ||||||
| CC (wild) | 31 (0.72) | 75 (0.78) | Ref | |||
| CT | 10 (0.23) | 20 (0.21) | 1.210 | 0.508-2.878 | 0.19 | 0.66664 |
| TT (variant) | 2 (0.05) | 1 (0.01) | 4.839 | 0.42-55.33 | 1.94 | 0.16417 |
| CT+TT | 12 (0.28) | 21 (0.22) | 1.382 | 0.607-3.150 | 0.60 | 0.43979 |
| C | 72 (0.84) | 206 (0.89) | Ref | |||
| T | 14 (0.16) | 22 (0.11) | 1.503 | 0.728-3.101 | 1.22 | 0.26848 |
| rs1136410 (Val > Ala) | PR+ | |||||
| Val/Val (wild) | 32 (0.65) | 75 (0.78) | Ref | |||
| Val/Ala | 13 (0.27) | 20 (0.21) | 1.523 | 0.677-3.43 | 1.04 | 0.30763 |
| Ala/Ala (variant) | 4 (0.08) | 1 (0.01) | 9.375 | 1.008-87.19 | 5.50 | 0.01906 |
| Val/Ala + Ala/Ala | 17 (35) | 21 (0.22) | 1.897 | 0.886-4.064 | 2.76 | 0.09686 |
| Val | 77 (0.79) | 206 (0.89) | Ref | |||
| Ala | 21 (0.21) | 22 (0.11) | 2.107 | 1.094-4.060 | 5.11 | 0.02383 |
| PR -ve | ||||||
| Val/Val (wild) | 28 (0.68) | 75 (0.78) | Ref | |||
| Val/Ala | 11 (0.27) | 20 (0.21) | 1.473 | 0.627-3.46 | 0.80 | 0.37246 |
| Ala/Ala (variant) | 2 (0.05) | 1 (0.01) | 5.357 | 0.467-61.42 | 2.24 | 0.13453 |
| Val/Ala + Ala/Ala | 13 (0.32) | 21 (0.22) | 1.658 | 0.733-3.752 | 1.49 | 0.22244 |
| Val | 67 (0.82) | 206 (0.89) | Ref | |||
| Ala | 15 (0.18) | 22 (0.11) | 1.730 | 0.847-3.535 | 2.30 | 0.12956 |
| rs1136410 (Val > Ala) | HER+ve | |||||
| Val/Val (wild) | 25 (0.66) | 75 (0.78) | Ref | |||
| Val/Ala | 10 (0.26) | 20 (0.21) | 1.5 | 0.620-3.63 | 0.81 | 0.36678 |
| Ala/Ala (variant) | 3 (0.08) | 1 (0.01) | 9.0 | 0.895-90.48 | 4.89 | 0.02706 |
| Val/Ala + Ala/Ala | 13 (0.34) | 21 (0.22) | 1.857 | 0.813-4.245 | 2.19 | 0.13911 |
| Val | 60 (0.79) | 206 (0.89) | Ref | |||
| Ala | 16 (0.21) | 22 (0.11) | 2.061 | 1.015-4.183 | 4.12 | 0.04241 |
| HER- ve | ||||||
| Val/Val (wild) | 35 (0.67) | 75 (0.78) | Ref | |||
| Val/Ala | 15 (0.29) | 20 (0.21) | 1.607 | 0.736-3.508 | 1.43 | 0.23141 |
| Ala/Ala (variant) | 2 (0.04) | 1 (0.01) | 4.286 | 0.376-48.86 | 1.61 | 0.20443 |
| Val/Ala + Ala/Ala | 17 (0.33) | 21 (0.22) | 1.735 | 0.815-3.69 | 2.07 | 0.1504 |
| Val | 85 (0.82) | 206 (0.89) | Ref | |||
| Ala | 19 (0.18) | 22 (0.11) | 1.727 | 0.887-3.365 | 2.62 | 0.10536 |