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. 2013 Dec 31;8(12):e85221. doi: 10.1371/journal.pone.0085221

Figure 2. HEK cells expressing NaV 1.3 and KIR 2.1 generate spontaneous electrical spikes.

Figure 2

A) Cartoon showing ion channels whose expression is sufficient to induce electrical spiking in a syncytial monolayer. B) Image of spiking HEK cells. A patch pipette is also visible. C) Patch clamp recording of membrane voltage in a single spiking HEK cell. D) Voltage-sensitive dye images showing electrical wave propagation in a culture of spiking HEK cells. E) Waves originated as self-reinforcing spirals. Videos S1-S4 show more propagation patterns in spiking HEK cells.