Figure 4. Subcellular Ca dynamics when a cell is paced with an AP clamp waveform.

(A) Periodic AP clamp. (B-C) AP clamp alternating in a LSLS and SLSL sequence respectively. AP clamp is taken from a recording of a single sarcomere paced at CL= 300 ms with stable Ca cycling (u=1.5 ms^-1). Initial conditions are chosen so that sarcomeres above (below) the 12th sarcomere start with opposite alternans phase.