Table 2. Risk of second cancer following NETs: univariable and multivariable Cox proportional hazards analysis, Taiwan, 1996-2008.
| Univariablea
|
Multivariableb
|
|||
|---|---|---|---|---|
| HR | 95% CI | HR | 95% CI | |
| Primary tumor site | ||||
| Rectum | Referent | Referent | ||
| Lung and bronchus | 1.67 | 0.69-4.03 | 1.32 | 0.54-3.21 |
| Stomach | 2.80 | 0.97-8.08 | 1.89 | 0.64-5.58 |
| Colon | 1.11 | 0.25-5.02 | 1.01 | 0.22-4.61 |
| Pancreas | 0.92 | 0.12-7.16 | 1.02 | 0.13-8.02 |
| Small intestine | 2.34 | 0.65-8.38 | 1.56 | 0.43-5.70 |
| Appendix | 2.46 | 0.78-7.44 | 2.08 | 0.66-6.58 |
| Head and neckc | 2.71 | 0.75-9.72 | 2.11 | 0.58-7.65 |
| Prostate | 31.71 | 6.87-146.35 | 15.21 | 3.19-72.44 |
| Biliary | - | - | - | - |
| Othersc | 2.11 | 0.87-5.12 | 2.12 | 0.87-5.17 |
| Sex | ||||
| Male | Referent | Referent | ||
| Female | 0.65 | 0.36-1.17 | 0.84 | 0.46-1.56 |
| Age | ||||
| Age<40 | Referent | Referent | ||
| 40<=age<50 | 1.54 | 0.45-5.27 | 1.45 | 0.42-5.00 |
| 50=<age<60 | 2.65 | 0.83-8.46 | 2.60 | 0.81-8.39 |
| 60=<age<70 | 1.74 | 0.49-6.19 | 1.71 | 0.48-6.14 |
| Age=>70 | 6.15 | 2.11-17.88 | 5.08 | 1.69-15.22 |
Abbreviations: CI = confidence interval; HR = hazard ratio
a Hazard ratio and 95% confidence interval were calculated using Cox proportional hazards model.
b Hazard ratio and 95% confidence interval were calculated using Cox proportional hazards model, adjusted for all of the variables in the table.
c Head and neck includes lip and oral cavity, pharynx, larynx, nasal cavity and paranasal sinuses, middle ear, and major salivary glands; Biliary includes gallbladder and extrahepatic bile duct; Others includes anus, bone, brain, cervix, intracranial gland, kidney, labia majora, mediastinum of the heart, peritoneum, pleura, retroperitoneum, skin, testis, thymus, thyroid, urinary bladder, uterus, vagina, and site undefined