Table 3. Standardized incidence ratio (SIR) of second cancers following NETs, Taiwan, 1996-2008.

	Observed N			Expected N			Overall			Male			Female
	Overall	Male	Female	Overall	Male	Female	SIR a	95% CI		SIR a	95% CI		SIR a	95% CI
Total cancer	49	32	17	33.12	22.53	10.60	1.48	1.09-1.96		1.42	0.97-2.01		1.60	0.93-2.51
Second cancer type
Colon	6	6	0	2.71	1.82	0.88	2.22	0.82-4.83		3.29	1.21-7.16		0.00
Lung	6	5	1	4.68	3.64	1.04	1.28	0.47-2.79		1.38	0.45-3.21		0.96	0.02-5.35
Breast	4	1	3	2.12	0.02	2.10	1.89	0.51-4.83		44.80	1.15-253.25		1.43	0.30-4.18
Rectum	3	2	1	2.07	1.45	0.62	1.45	0.30-4.24		1.38	0.17-4.97		1.62	0.04-9.01
Liver/intrahepatic bile duct	5	3	2	4.96	3.78	1.18	1.01	0.33-2.35		0.79	0.16-2.32		1.70	0.21-6.14
Prostate	3	3	0		1.98					1.52	0.31-4.43
Bladder	4	3	1	1.09	0.88	0.21	3.68	1.00-9.43		3.42	0.71-10.00		4.78	0.62-1.37
Kidney/renal pelvis/urethra	4	3	1	0.89	0.57	0.32	4.48	1.22-11.48		5.25	1.08-15.35		3.11	0.79-17.66
Esophagus(include EC junction)	3	2	1	2.76	2.25	0.51	1.09	0.22-3.17		0.89	0.18-3.21		1.96	0.05-10.90
Small intestine/pancreas	2	1	1	0.79	0.55	0.23	2.55	0.31-9.19		1.81	0.05-10.09		4.28	0.11-23.91
Cervix/uterus	2	0	2			1.05							1.90	0.23-6.87
Others b	7	3	4	2.26	1.34	0.91	3.10	1.25-6.40		2.24	0.46-6.53		4.38	1.19-11.22

Abbreviations: CI = confidence interval; N = number; SIR = standardized incidence ratio

^a SIR = observed N/expected N

^b Others: soft tissue (N=2), skin (N=1), peritoneum (N=1), thyroid (N=1), and ill-defined (N=2)