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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: Biochim Biophys Acta. 2013 May 31;1838(2):10.1016/j.bbamem.2013.05.024. doi: 10.1016/j.bbamem.2013.05.024

Figure 1. Regulation of ENaC by Nedd4–2.

Figure 1

A–B. The ubiquitin ligase Nedd4–2 recognizes PY motifs in wild type ENaC but not mutated forms of the β or γ subunits, which lack the PY motif. C. Ubiquitinated ENaC is endocytosed, leading to a reduction in ENaC at the plasma membrane, reducing activity. On the other hand, mutated forms of ENaC, that are resistant to ubiquitination, remain at the plasma membrane, and increase channel activity.