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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: Biochim Biophys Acta. 2013 May 31;1838(2):10.1016/j.bbamem.2013.05.024. doi: 10.1016/j.bbamem.2013.05.024

Figure 2. Regulation of IKs by the AKAP Yotiao.

Figure 2

A. The IKs channel consists of KCNQ1 α-subunits and KCNE1 β-subunits. The AKAP Yotiao complexes protein kinase A (PKA) and protein phosphatase 1 (PP1) to the IKs channel. Stimulation of the β-adrenergic receptor (β-AR) leads to activation of adenylate cyclase, the production of cAMP, and activation of protein kinase A. PKA and PP1 regulate IKs via phosphorylation/dephosphorylation activities. B. Mutations which disrupt the association between Yotiao and the IKs channel complex become insensitive to β-adrenergic stimulation.