Table 3. Baseline to 6-month changes in outcome measures for women who completed 6-month program—internet-based wellness information and nutrition education group sessions (WI+GS) vs wellness information only (WI).
| WI+GS (n=69) | WI (n=70) | Time effect P-value | Treatment effect P-value | Treatment × time effect P-value | |
|---|---|---|---|---|---|
| Adiposity | |||||
| Weight (kg) | −2.7±3.9 | −2.0±3.9 | <0.001 | 0.784 | 0.332 |
| Fat mass (kg) | −2.2±3.1 | −1.7±3.7 | <0.001 | 0.148 | 0.411 |
| Truncal fat (%) | −1.8±2.9 | −1.3±3.1 | <0.001 | 0.143 | 0.423 |
| Abdominal circumference (cm) | −3.4±5.2 | −2.7±5.4 | <0.001 | 0.266 | 0.461 |
| Hip circumference (cm) | −2.4±4.6 | −1.1±4.2 | <0.001 | 0.920 | 0.154 |
| Exercise performance | |||||
| Duration (s) | +47±60 | +50±69 | <0.001 | 0.408 | 0.754 |
| Peak VO2 (ml kg−1 min−1) | +1.7±3.1 | +1.5±3.1 | <0.001 | 0.522 | 0.754 |
| Insulin sensitivity | |||||
| HOMA | −0.5±1.0 | −0.1±1.3 | <0.001 | 0.906 | 0.099 |
| Lipids (n=65, 69) | |||||
| Total cholesterol (mg dl−1) | −13±25 | −8±23 | <0.001 | 0.313 | 0.252 |
| LDL-cholesterol (mg dl−1) | −8±18 | −5±23 | <0.001 | 0.978 | 0.458 |
| HDL-cholesterol (mg dl−1) | −2±10 | −2±8 | 0.016 | 0.034 | 0.587 |
| Triglycerides (mg dl−1) | −10±32 | −9±29 | <0.001 | 0.577 | 0.867 |
Abbreviations: BMI, body mass index (weight divided by squared height); HDL, high-density lipoprotein; HOMA, homeostasis model assessment; LDL, low-density lipoprotein; VO2, oxygen consumption.
Lipid measurements reported for subjects not taking HMG-CoA reductase inhibitor (statin) medications. Data are presented as mean values±s.d.
Repeated-measures mixed-effects models (adjusted for age, race and baseline BMI) were used to assess the effect of 6 months participation (time) and WI+GS vs WI assignment (treatment) on the primary outcome of weight loss and all secondary outcomes.