Figure 2.
HFCS induces severe adipose tissue inflammation. Relative insulin receptor substrate 1 (IRS-1) and Glut4 expression in (a) skeletal muscle, (b) liver and (c) epididymal fat (EPI). (d) Percentage of EPI depot from the 12-month-old WT mice fed with either RD, HFD or HFCS for 10 months. Flow cytometry analysis of (e) total ATMs, (f) proinflammatory F4/80+CD11c+ and anti-inflammatory F4/80+CD11c− ATMs in the EPI. n=6–8; *P<0.05, **P<0.001, RD vs HFCS or HFD; #P<0.05, HFCS vs HFD, respectively.