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. 2013 Dec 23;3(12):e99. doi: 10.1038/nutd.2013.41

Figure 3.

Figure 3

GHS-R ablation attenuates HFCS-induced insulin resistance independent of obesity. The WT and Ghsr−/− mice were fed either RD or HFCS starting from 2 months of age. (a) Total ghrelin levels of different diet-fed mice at 12 months of age. Mice were fasted overnight. (b and c) Body weight and body composition of the mice at 10 months of age. (d) Weekly calorie intake of the mice collected between 5 and 6 months of age. Calories were calculated from both solid diet and HFCS drink. ITTs and GTTs were carried out at 8 months of age. (e) Glucose levels during ITT. (f) Glucose and insulin levels of HFCS-fed mice during GTT. n=6–8; *P<0.05, **P<0.001, Ghsr−/− vs WT mice; #P<0.05, HFCS vs RD within WT or Ghsr−/− mice, respectively.