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β1- and β2-adrenergic receptor levels are down-regulated in paediatric heart failure patients. (A) Antithetical regulation of β1- and β2-adrenergic receptor mRNA levels in paediatric and adult heart failure patients. P-values correspond to failing-to-non-failing comparisons unless otherwise noted in the figure. (B) β-Adrenergic receptor levels were determined by [125I]-iodocyanopindolol binding. AR, adrenergic receptor; F, failing; NF, non-failing; Bmax, total β-adrenergic receptor.
