Figure 3.

oAβ-induced caspase-1 activation is dependent on NLRP3. (a) LPS-primed microglia were treated with NaCl or KCl before oAβ stimulation, and IL-1β in the culture supernatant was measured at 48 h. Data indicate means±S.D. for four independent experiments. ***P<0.001, versus LPS-primed microglia (ctl). ^†††P<0.001, versus LPS priming+oAβ+KCl. (b) LPS-primed microglia were treated with oAβ for 48 h, and co-localization of NLRP3 and caspase-1 were assessed by immunocytochemistry. Data are representative of three independent experiments. Scale bar represents 10 μm