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. 2013 Dec 19;4(12):e975. doi: 10.1038/cddis.2013.503

Figure 4.

Figure 4

oAβ-induced IL-1β release is independent on phagocytosis or cathepsin B. LPS-primed microglia were treated with cytochalasin D for 30 min before oAβ stimulation, and IL-1β (a) in the culture supernatant as well as caspase-1 activity (b) were measured at 48 h. Data indicate means±S.D. for three independent experiments. ***P<0.001, versus LPS-primed microglia (ctl). ns indicates not significant. LPS-primed microglia were treated with cathepsin B inhibitor for 30 min before oAβ stimulation, and IL-1β (c) in the culture supernatant as well as caspase-1 activity (d) were measured at 48 h. Data indicate means±S.D. for three independent experiments. ***P<0.001, versus LPS-primed microglia (ctl). ns indicates not significant