Table 2.
Selected commercially available mix-mode media.
| Media | Supplier | Type | Ligand | pH stability |
|---|---|---|---|---|
| CHT ceramic hydroxyapatite | Bio-Rad laboratories | Ion exchange, metal chelation | [Ca5[PO4]3OH]2 | Operating pH: 5.5–14 Can be cleaned with 1-2 M NaOH |
| CHT Fluorapatite | Bio-Rad laboratories | Ion exchange, metal chelation | [Ca10[PO4]6F]2 | Operating pH: 5–14 Can be cleaned with 1-2 M NaOH |
| MEP | Pall life sciences | Hydrophobic binding near neutral pH, elution by pH reduction | 4-Mercapto ethyl pyridine | Working pH: 2–12 Cleaning pH: 2–14 |
| HEA | Pall life sciences | Hydrophobic binding near neutral pH, elution by pH reduction | Hexylamino | Working pH: 2–12 Cleaning pH: 1–14 |
| PPA | Pall life sciences | Hydrophobic binding near neutral pH, elution by pH reduction | Phenylpropylamino | Working pH: 2–12 Cleaning pH: 1–14 |
| MBI | Pall life sciences | Hydrophobic binding at acidic pH, elution by raising the pH | 2-Mercapto-5-benzimidazole sulfonic acid | — |
| Capto MMC | GE Healthcare | Multimodal cation exchange | 2-Benzamido-4-mercaptobutanoic acid | Long term: 2–12 Short term: 2–14 |
| Capto adhere | GE Healthcare | Multimodal strong anion exchange | N-benzyl-N-methyl ethanolamine | Long term: 3–12 Short term: 2–14 |