Table 1.
Relationship between postprandial colon motility parameters and metabolite changes
| Motility parameter (N) | Metabolite | Time point after the meal (min) | Change* (↓ or ↑) | P-value |
|---|---|---|---|---|
| Motility index | ||||
| Increase (13) | None | |||
| No increase (7) | Glycerol | 10 | ↑ | 0.019 |
| Carnosine | 30 | ↑ | 0.015 | |
| Number of peaks | ||||
| Increase (14) | Alanine | 0 | ↑ | 0.03 |
| Alanine | 10 | ↑ | 0.03 | |
| No increase (6) | Glycerol | 10 | ↑ | 0.02 |
| Peak frequency | ||||
| Increase (13) | Alanine | 0 | ↑ | 0.03 |
| Asparagine | 60 | ↑ | 0.04 | |
| Cytosine | 0 | ↑ | 0.015 | |
| Cytosine | 10 | ↑ | 0.01 | |
| Cytosine | 60 | ↑ | 0.015 | |
| No increase (7) | None | |||
| Peak amplitude | ||||
| Increase (5) | Cytosine | 10 | ↑ | 0.03 |
| Choline | 0 | ↑ | 0.03 | |
| Phosphocholine | 30 | ↑ | 0.03 | |
| Thyroxine | 10 | ↑ | 0.03 | |
| Triiodothyronine | 10 | ↑ | 0.03 | |
| No increase (15) | None | |||
| AUC | ||||
| Increase (9) | None | |||
| No increase (11) | 5HIAA | 60 | ↑ | 0.015 |
| Adenosyl-homocysteine | 0 | ↑ | 0.006 | |
| Adenosyl-homocysteine | 10 | ↑ | 0.001 | |
| Adenosyl-homocysteine | 60 | ↑ | 0.04 | |
| Deoxyadenosine | 0 | ↑ | 0.04 | |
| GABA | 30 | ↑ | 0.03 | |
| Histamine | 0 | ↑ | 0.04 | |
| Isoleucine | 30 | ↑ | 0.02 | |
| Kynurenic acid | 0 | ↑ | 0.003 | |
| Kynurenic acid | 10 | ↑ | 0.01 | |
| Kynurenic acid | 30 | ↑ | 0.01 | |
| Kynurenic acid | 60 | ↑ | 0.01 | |
| Triiodothyronine | 10 | ↑ | 0.02 | |
| Valine | 30 | ↑ | 0.02 |
*
Comparison between patient groups with an ‘increase’ or ‘no increase’ in each of the motility parameters listed. Time point 0 corresponds to the baseline, before meal was ingested.