Table 1.
Effect of different doses of Diazoxide (mg/kg) on the various stages of seizures induced by Dichlorvos injection in mic (data are shown as percentage of mice, n = 10). Stage 0: no abnormal behavior; Stage 1: excessive salivation, chewing, and pawing of whiskers and mouth; Stage 2: dazed appearance, intermittent motionlessness, tremor, and/or bobbing of the head; Stage 3: like Stage 2, with random and/or generalized jerks; Stage 4: intermittent rearing on hind legs with forepaws extended (with clonic jerking) without falling; Stage 5: like Stage 4, with falling to the side or rear; Stage 6: status epilepticus.
| Treatment | Stage of seizures | ||
|---|---|---|---|
| Stage 0 | Stage 1–3 | Stage 4–6 | |
| Dichlorvos | 0 | 0 | 100 |
| Diazoxide 1 + Dichlorvos | 0 | 0 | 100 |
| Diazoxide 2.5 + Dichlorvos | 10 | 20 | 70 |
| Diazoxide 5 + Dichlorvos | 30 | 20 | 50 |
| Diazoxide 10 + Dichlorvos | 60 | 10 | 30 |
| Diazoxide 20 + Dichlorvos | 80 | 10 | 10 |