Figure 3.

Characterization of MAP3K1 alterations in breast cancer. (A) Somatic mutations found in MAP3K1 gene by the TCGA Breast Invasive Carcinoma study are predicted to be loss-of-function. The mutations are represented by circles: nonsense, splicing mutations, frameshift deletion, and insertion (red), missense mutations (green), and inframe deletion (black). (B) MAP3K1 alterations in breast cancer are mutually exclusive with those of MAP2K4 and partially overlap with those of PIK3CA. Shown is the oncoprint of MAP3K1, MAP2K4, and PIK3CA genes, in which individual samples are represented as columns and individual genes are represented as rows. Subtype assignment and disease-free status of the patients are shown in the first 2 rows. The data were obtained and visualized by cBioPortal database using the TCGA Breast Invasive Carcinoma data set with modifications.