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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: Neurobiol Dis. 2013 Oct 2;62:10.1016/j.nbd.2013.09.018. doi: 10.1016/j.nbd.2013.09.018

Table 3.

Main effects observed during previous studies by the Butterfield group about (i) oxidative stress levels and (ii) HO-1/BVR-A system in the brain and liver of aged beagles following atorvastatin treatment. Each value is expressed with respect to the control group (Barone et al., 2012b; Butterfield et al., 2012a).

Parietal Cortex Cerebellum Liver
PC total levels Inline graphic 11%, * ≠ ≠
HNE total levels Inline graphic 32%, * ≠ ≠
3-NT total levels Inline graphic 26%, * ≠ ≠
HO-1protein levels Inline graphic 75%, ** ≠ ≠
BVR-A protein levels Inline graphic 21%, * ≠ Inline graphic 60%, **
pTyr-BVR-A Inline graphic 54%, * ≠ ≠
pSer/Thr-BVR-A Inline graphic 17% ≠ ≠
BVR activity Inline graphic 35%, * ≠ ≠
PC-BVR-A ≠ ≠ Inline graphic 60%, ns
HNE-BVR-A ≠ ≠ Inline graphic 60%, **
3-NT-BVR-A Inline graphic 18%, ns ≠ ≠

Inline graphic Increase, Inline graphic decrease, ≠ no changes,

*

p<0.05,

**

p<0.01,

ns non significant