. Author manuscript; available in PMC: 2015 Jan 1.

Published in final edited form as: Pflugers Arch. 2013 Oct 6;466(1):10.1007/s00424-013-1370-5. doi: 10.1007/s00424-013-1370-5

Table 2.

Functions of NKCC1 and NKCC2

NKCC1		NKCC2

Localization	Function	Localization	Function

Inner ear	Hearing and balance	Kidney: TAL	Na⁺ reabsorption, NH₄⁺ reabsorption
Sensory neurons	Filtering sensory noise	Kidney: macula densa	Na⁺ sensing (tubuloglomerular feedback)
CNS neurons	Proconvulsant or anticonvulsant
Salivary gland epithelial cells	Salivary volume
Intestine interstitial Cajal cells	Peristalsis
Vascular smooth muscle cells	Vascular tone
testes	Spermatogenesis
Airway epithelial cells	Maturation of fetal lung
Distal colon	NH₄⁺ secretion