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. Author manuscript; available in PMC: 2014 Jan 1.
Published in final edited form as: Mol Cancer Res. 2012 Oct 4;10(12):10.1158/1541-7786.MCR-12-0168. doi: 10.1158/1541-7786.MCR-12-0168

Figure 5.

Figure 5

Biological processes necessary for survival after alkylation damage are conserved and when compiled generate a cross-species functionome. The conserved biological processes with their corresponding genes were visualized using Cytoscape. Red nodes denote conserved biological processes. The remaining nodes are alkylation-modulating proteins belonging to E. coli (dark blue), S. cerevisiae (light blue) and humans (light green). The edges connect specific biological processes to each protein belonging to the processes. Many proteins are involved in more than one biological process to affect alkylation exposure survival and therefore are connected to several biological processes nodes.