. Author manuscript; available in PMC: 2014 Jan 1.

Published in final edited form as: Mol Cancer Res. 2012 Oct 4;10(12):10.1158/1541-7786.MCR-12-0168. doi: 10.1158/1541-7786.MCR-12-0168

Table 2.

Sensitizing DNA glycosylases and their known substrates

Gene Symbol	Gene Name	Known Substrate^*	Screen Viability Ratio
OGG1	8-oxoguanine DNA glycosylase	8-oxoG:C=T=G; me-FapyG:C; FapyG:C; 8-oxoA:C; urea	0.648
UNG	Uracil DNA glycosylase	ssU; U:G; U:A; 5-fluorouracil; 5,6-Dihydroxy-U:G; 5-OH-U:G; Isodialuric acid; Alloxan	0.446
TDG	Thymine DNA glycosylase	U:G; T:G and ethenoC:G; 5-Fluorouracil; 5-fluorouracil (ss); 5-Hydroxymethyluracil; hypoxanthine:G; 5-bromouracil; εC:A Tg:G; 5-formyl-U	0.541
NEIL1	Nei endonuclease VIII-like 1 (E. coli)	TgG; 5-OH-C; 5-OH-U:AT>G; Guanidinohydantoin; guanidinohydantoin (ss); Iminoallantoin; Iminoallantoin (ss); Spiroiminodihydantoin; Spiroiminodihydantoin (ss); 5,6-Dihydro-T; 5,6-Dihydro-U:G=C=A>T; FapyG:C; 8-Oxo-G:C=G>T>A; FapyA:T; (5’R)-8,5’-Cyclo-2’-deoxyadenosine; (5’S)-8,5’-Cyclo-2’-deoxyadenosine; 8-Oxo-A:C	0.559

For mismatched base pairs, the repaired or removed base is configured on the left in each case.