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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: Neurobiol Dis. 2013 Oct 21;62:10.1016/j.nbd.2013.10.015. doi: 10.1016/j.nbd.2013.10.015

Figure 1. Location and evolutionary conservation of NaV1.3 variants.

Figure 1

(A) Predicted transmembrane topology of NaV1.3 depicting the location of the variants (●) characterized in this study. The grey rectangle behind the depiction represents the plasma membrane. The S4 segments are illustrated as black cylinders with plus (+) signs. (B) Multiple alignment of human homologs and species orthologs of NaV1.3 (Clustal Omega; Sievers et al, 2011). The variant amino acids are shaded to highlight conservation at the variant positions.