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. Author manuscript; available in PMC: 2014 Nov 1.
Published in final edited form as: Hepatology. 2013 Aug 19;58(5):1742–1756. doi: 10.1002/hep.26521

Figure 6.

Figure 6

(A) OPN protein expression and secretion to cell supernatant in HSC incubated with mediators of liver injury up to 48 hours (*P<0.05 vs. basal). (B) OPN gene expression in mouse liver slices incubated with LPS up to 48 hours (*P<0.05 vs. LPS 0 µg/ml). (C) OPN gene expression in RAW264 cells incubated with LPS up to 24 hours (*P<0.05 vs. LPS 0 ng/ml). (D) MCP-1 and ICAM-1 gene expression in HSC incubated with recombinant OPN up to 24 hours (*P<0.05 vs. OPN 0 µg/ml, **P<0.01 vs. rhOPN 0 µg/ml). (E) Activation of intracellular signaling pathways in HSC incubated with recombinant OPN up to different short times (*P<0.05 vs. time 0 min.).