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Model depicting an inverted-U relationship of dopamine D1 receptor (DRD1) signaling, which accounts for interacting effects of COMT and DARPP-32 genetic polymorphisms on working memory (WM) performance. Intermediate levels of DRD1 signaling, which we propose are acting at the level of the PFC, are hypothesized to enable optimal discrimination of target stimuli from interfering stimuli under high WM load.
