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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: Neurobiol Dis. 2013 Sep 17;62:10.1016/j.nbd.2013.08.018. doi: 10.1016/j.nbd.2013.08.018

Figure 9.

Figure 9

The effect of P/Q-type calcium channel blocker on GABA release was increased in epileptic animals. Representative recordings of sIPSC recording from naïve (A) and epileptic (B) rat DGCs with 10 min baseline, 15 min ω-agatoxin TK (Agtx) application and 15 min Agtx with WIN. Cumulative probability plots of the sIPSC inter-event intervals (C) and amplitude (D) in naïve rats (average of 8 neurons) before (continuous line), and after application of Agtx (larger dashed lines) and Agtx with WIN (small dashed lines). Cumulative probability plots of the sIPSC inter-event intervals (E) and amplitude (F) in epileptic rats (average of 8 neurons) before (continuous line), and after application of Agtx (larger dashed lines) and CTX with WIN (small dashed lines). Quantification of the effect of Agtx and Agtx with WIN on the frequency (G) and amplitude (H) of sIPSC in naïve (filled column) and epileptic (empty column) rats (means ± SEM).