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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: Neurobiol Dis. 2013 Oct 19;62:10.1016/j.nbd.2013.10.013. doi: 10.1016/j.nbd.2013.10.013

Fig. 2.

Fig. 2

Neuroprogenitor cells carrying the LRRK2 G2019S mutation show more mtDNA damage than neuroprogenitor cells from iPSCs of a healthy sibling without the LRRK2 G2019S mutation. (A) Neuroprogenitor cells were differentiated from iPSCs carrying the LRRK2 G2019S mutation (black bar) and from a healthy sibling (white bar). mtDNA lesions were increased in neuroprogenitor cells carrying the LRRK2 G2019S mutation (clone L4a, Supplemental Table 1) relative to mtDNA from healthy sibling (clone C3, Supplemental Table 1). QPCR-based assay was performed in triplicate with three experimental replicates. Data are presented as mean ± SEM, *p = 0.0002.