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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: Neurobiol Dis. 2013 Oct 10;62:10.1016/j.nbd.2013.10.001. doi: 10.1016/j.nbd.2013.10.001

Figure 1.

Figure 1

Type IIb case (3.6 yr) with pharmacoresistant epileptic seizures since the age of 10 m. A. During surgery, the ECoG showed continuous epileptic discharges, typical of CD, in the parietal region (white circles) but not in the temporal region. PGA was found in the parietal sample. Yellow circles indicate the areas where the tissue samples for electrophysiology were taken. Each vertical green line on the ECoG trace represents 1 sec. B. Coronal (left) and axial (right) MRI T2 scans showing the areas with highest anatomical abnormality (white circles). C. The two left panels show NeuN immunostained sections of relatively normally organized neocortex and markedly disorganized neocortex. Disorganized cortex shows crowding and abnormal orientation of many immunoreactive cells (in both pictures the piamater is on top). Calibration applies to both panels. Near right panel: Klüver-Barrera stained section shows dysmorphic neurons with abnormal Nissl substance and cell processes (arrowheads). Far right panel: Hematoxylin and eosin (H&E) stained section showing balloon, binucleated cells (arrowheads). Calibration applies to both panels.