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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: Neurobiol Dis. 2013 Oct 10;62:10.1016/j.nbd.2013.10.001. doi: 10.1016/j.nbd.2013.10.001

Figure 2.

Figure 2

A. Whole-cell voltage clamp recording demonstrating PGA in a normal-like pyramidal neuron (B) from a CD Type Ib case. Pathological analysis revealed cytoarchitectural abnormalities as demonstrated by blurring of most cortical layers. No dysmorphic or “balloon” cells were observed. Bath application of the GABAA receptor antagonist BIC (20 μM) abolished PGA. After BIC washout PGA slowly recovered. C. Holding the membrane at different voltages demonstrated a reversal potential of PGA around −60 mV, which closely corresponds to the predicted reversal potential based on the Cl− concentration in the internal solution. Traces on the right are the corresponding average of spontaneous GABA synaptic events at different holding potentials. D. The current-voltage relationship reveals a reversal potential around −60 mV. Interestingly, the current amplitude values at different holding potentials were better fit with a sigmoid, not a linear, function.