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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: Neurobiol Dis. 2013 Oct 10;62:10.1016/j.nbd.2013.10.001. doi: 10.1016/j.nbd.2013.10.001

Figure 5.

Figure 5

PGA is dependent on action potentials and is not affected by glutamate receptor blockade. A. Normal-sized, biocytin-filled pyramidal neuron from a CD Type Ib case. Arrowheads indicate dendritic blebbing. B. PGA recorded at a holding potential of +10 mV in standard solution. Bath application of a selective NMDA receptor antagonist, APV, in conjunction with a non-NMDA receptor antagonist, NBQX, produced no discernible effect on PGA. In contrast, Na+ channel block with TTX completely abolished PGA, leaving only random mIPSCs. C. Autocorrelation histograms associated with traces shown in B. Note the lack of auto-correlation after blockade of Na+ channels.