Table 2.
Mouse proteins less abundant in S. aureus-infected mouse abscesses from neutropenic mice as compared to wildtype mice.
| Proteina | Neub | WTc | Neu/WTf | p valueg | ||
|---|---|---|---|---|---|---|
| Meand | SDe | Meand | SDe | |||
| Innate Immunity | ||||||
| Myeloid bactenecin (Neutrophilic granule protein) | 24 | 12.75 | 295 | 33.99 | 0.08 | 0.0034 |
| Lactotransferrin precursor | 67 | 45.00 | 278 | 47.77 | 0.24 | 0.0044 |
| Annexin A1 | 53 | 13.40 | 218 | 23.58 | 0.24 | 0.0162 |
| Lysozyme C type M precursor | 41 | 10.59 | 186 | 23.43 | 0.22 | 0.0033 |
| Myeloperoxidase | 67 | 15.48 | 135 | 24.28 | 0.49 | 0.0121 |
| Neutrophil gelatinase-associated lipocalin precursor | 17 | 10.71 | 120 | 32.24 | 0.14 | 0.0303 |
| Lymphocyte cytosolic protein 1 | 12 | 2.86 | 62 | 0.00 | 0.20 | 0.0366 |
| CD177 antigen | 9 | 3.32 | 52 | 5.17 | 0.17 | 0.0258 |
| Leukocyte elastase precursor | 5 | 5.14 | 38 | 0.00 | 0.14 | 0.0020 |
| Cathelin-related antimicrobial peptide precursor | 0 | 0.00 | 35 | 6.37 | 0.00 | 0.0116 |
| S100-A11 | 2 | 3.01 | 30 | 5.52 | 0.06 | 0.0359 |
| Antioxidants | ||||||
| Peroxiredoxin-5 | 45 | 8.94 | 149 | 17.30 | 0.30 | 0.0001 |
| Cytoskeleton and ECM | ||||||
| Myosin heavy chain IX | 145 | 14.56 | 334 | 8.63 | 0.43 | 0.0002 |
| Filamin, alpha | 18 | 8.35 | 107 | 9.01 | 0.16 | 0.0009 |
| Integrin alpha M | 2 | 3.25 | 59 | 0.00 | 0.03 | 0.0098 |
| Integrin beta-2 precursor | 5 | 5.21 | 51 | 0.00 | 0.10 | 0.0018 |
| Lamin-B receptor | 5 | 0.27 | 27 | 0.00 | 0.19 | 0.0083 |
| Talin-1 | 5 | 5.64 | 25 | 0.00 | 0.22 | 0.0141 |
| Actin related protein 2/3 complex | 0 | 0.00 | 6 | 0.00 | 0.00 | 0.0002 |
| Histones | ||||||
| Histone 4 | 349 | 35.50 | 722 | 141.44 | 0.48 | 0.0262 |
| Hist1h2bj protein | 135 | 29.69 | 365 | 44.21 | 0.37 | 0.0149 |
| Histone cluster 1, H3g | 31 | 14.60 | 67 | 15.63 | 0.46 | 0.0457 |
| Heterogeneous nuclear ribonucleoprotein C | 0 | 0.00 | 21 | 5.98 | 0.00 | 0.0268 |
| General Cell Processes | ||||||
| Alpha-enolase | 81 | 21.19 | 171 | 43.41 | 0.48 | 0.0404 |
| Aldo-keto reductase family 1, member A4 | 57 | 7.28 | 149 | 11.70 | 0.39 | 0.0009 |
| Nucleoside diphosphate kinase A | 15 | 5.09 | 55 | 3.19 | 0.28 | 0.0258 |
| Phosphoglycerate mutase 1 | 14 | 5.36 | 39 | 7.03 | 0.35 | 0.0167 |
| Phosphogluconate dehydrogenase | 13 | 3.78 | 36 | 0.00 | 0.35 | 0.0242 |
| NADH dehydrogenase (ubiquinone) Fe-S protein 1 | 5 | 5.14 | 19 | 0.00 | 0.27 | 0.0415 |
| Miscellaneous | ||||||
| Chitinase 3-like protein 3 precursor | 195 | 17.21 | 388 | 28.58 | 0.50 | 0.0005 |
| Kidney-specific protein homolog | 102 | 10.18 | 224 | 46.92 | 0.45 | 0.0291 |
| Peptidyl-prolyl cis-trans isomerase A | 53 | 8.03 | 148 | 29.75 | 0.36 | 0.0456 |
| Rho GDP-dissociation inhibitor 2 | 23 | 12.10 | 99 | 21.34 | 0.23 | 0.0030 |
| Selenium binding protein 1 | 21 | 12.02 | 69 | 10.72 | 0.30 | 0.0113 |
| 14–3–3 protein zeta/delta | 19 | 7.48 | 53 | 3.35 | 0.36 | 0.0061 |
| Guanine nucleotide binding protein, alpha inhibiting 2 | 12 | 2.67 | 32 | 0.00 | 0.39 | 0.0182 |
| Myeloblastin precursor | 3 | 5.67 | 16 | 5.17 | 0.21 | 0.0488 |
| Rpl30 protein | 3 | 2.99 | 13 | 3.18 | 0.26 | 0.0144 |
| RAN, member RAS oncogene family | 2 | 3.01 | 11 | 0.00 | 0.16 | 0.0370 |
| Guanine nucleotide binding protein, alpha inhibiting 3 | 0 | 0.00 | 11 | 0.00 | 0.00 | 0.0342 |
a
Protein identification based on UniRef and NCBI database searches.
b
Neutropenic mouse.
c
Wildtype mouse.
d
Mean of the number of spectra detected in the three technical replicate samples analyzed for this condition.
e
Standard deviation among the number of the spectra detected in the three technical replicate samples analyzed for this condition.
f
Ratio of the mean of the number of spectra detected in the neutropenic mouse to that in the wildtype mouse.
g
p-value as obtained by applying Student’s t-test.