Table 1.
Demographic and clinical characteristics at entry
| Characteristic | CDR 0 | CDR 0.5 | CDR 1 | CDR 2 or 3 | |
|---|---|---|---|---|---|
| Noncarrier | Carrier | ||||
| N | 96 | 89 | 40 | 18 | 6 |
| Age (yrs) | 40.4 (9.6) | 34.6 (8.7) | 44.1 (10.3) | 45.8 (8.1) | 54.3 (8.3) |
| Education (yrs) | 14.7 (2.6) | 14.4 (2.5) | 14.2 (2.5) | 12.9 (2.6) | 13.0 (2.4) |
| Time to onset (yrs) | − 6.6 (11.9) | −12.7 (8.1) | −1.9 (7.7) | 3.9 (5.6) | 1.5 (10.6) |
| Women (%) | 59 | 60 | 60 | 56 | 50 |
| APOE 1 E4 (%) | 28 | 22 | 26 | 6 | 17 |
| APOE 2 E4 (%) | 0 | 2 | 5 | 6 | 17 |
| CDR Sum of boxes | 0.0 (0.1) | 0.0 (0.1) | 1.5 (1.0) | 5.8 (1.0) | 13.5 (3.4) |
| MMSE | 29.1 (1.3) | 29.1 (1.3) | 26.8 (3.0) | 17.9 (4.9) | 9.5 (6.4) |
| FAQ | 0.1 (0.3) | 0.2 (0.8) | 2.5 (3.2) | 16.6 (6.6) | 26.8 (4.5) |
| Hachinski | 0.2 (0.7) | 0.1 (0.4) | 0.7 (1.4) | 0.5 (0.7) | 0.8 (1.0) |
| GDS | 1.2 (1.5) | 1.4 (1.8) | 3.6 (3.3) | 4.4 (3.0) | 2.0 (2.2) |
Entries are means with SDs in parentheses unless otherwise specified. Time to onset is time to expected symptomatic onset; MMSE = MiniMental Status Exam; FAQ = Functional Activities Questionnaire; GDS = Geriatric Depression Scale.