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. Author manuscript; available in PMC: 2014 Dec 18.
Published in final edited form as: Neuron. 2013 Dec 5;80(6):10.1016/j.neuron.2013.10.057. doi: 10.1016/j.neuron.2013.10.057

Figure 1. Anatomical Location of the Intracranial Electrodes and Electroencephalographic Activity.

Figure 1

In P1 (A) and P2 (B) electrical stimulation was bipolar between contacts 1 and 2. As noted in the magnetic resonance images (MRIs) and the electroencephalographic (EEG) traces, contacts 1 and 2 in P1 and contact 1 in P2 were clearly in the gray matter. Because the EBS was performed in a bipolar manner (i.e., between electrode contacts 1 and 2), we attribute the results of the EBS to the engagement of the aMCC gray matter and its white matter connections with other brain regions. Note the decrement of EEG activity between sites 2–3 compared to the activity recorded between sites 1 and 2. The MNI coordinates of the EBS targets were as follows: P1 (electrode 1=; 2.00, 26.00, 26.00; electrode 2=8.00, 26.00, 26.00) and P2 (electrode 1=10.00, 18.00, 26.00; electrode 2=16.00, 20.00, 26.00). Note that the right side of the image corresponds to the right side of the brain. One second (1s) EEG time scale shown. Sites of stimulation in the subgenual and retrosplenial regions are shown as controls sites 1 or 2 (C1 and C2 – blue filled circles). Besides these cingulate control regions, sites immediately adjacent to the aMCC were also stimulated as control sites (see Table 1). Stimulation of these control sites did not elicit similar cognitive and emotional effects as the stimulation of the aMCC sites.