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. 2014 Jan 2;4:301. doi: 10.3389/fgene.2013.00301

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Copyright © 2014 Song and Rossi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Model for anti-miR21 activity. (A) TGS and PTGS models for mechanism by which anti-miR21 inhibits miR21. (B) Model for mechanism by which anti-miR21 inhibits miR30. Anti-miR21 blocks miR30 on the basis of matching sequence. I. The structure of pri-miR30. Red bar indicates hybrid area of anti-miR21, as identified by CLC Bio Main Workbench software. Highlighted sequence is mature miR30. II. Pri-miR30 is normally processed into mature miR30 through the normal miRNA mechanism. III. The structure of pri-miR30 can be changed by anti-miR21. IV. Sequence alignment of pri-miR30 (upper sequence) with anti-miR21 (red sequence). Gray sequence shows the mature miR30.