Table 1.
Cytotoxic inhibitory concentrations, selectivity indexes and HIV-1 PR inhibitory concentrations of the nine isolated compounds in different cell lines.
| Compound | Cytotoxicity IC50 (µM) | SI Values | IC50 (µM) | |||
|---|---|---|---|---|---|---|
| HeLa | Vero | U937 | HeLa | U937 | HIV-1 PR | |
| 1 | 27.5 ± 0.2 | 22 ± 0.2 | 31.7 ± 3.2 | 0.8 | 0.75 | 15.7 ± 0.10 |
| 2 | 30 ± 17.2 | 49 | N/T | 1.6 | N/T | 7.2 ± 0.7 |
| 3 | 48 ± 8.7 | 100 ± 1.2 | N/T | 2.1 | N/T | N/T |
| 4 | 38 ± 0.7 | 49.8 ± 0.5 | 50 ± 0.23 | 1.3 | 1.00 | N/T |
| 5 | >100 | >100 | >100 ± 0.04 | N/A | N/A | N/T |
| 6 | 23.35 ± 5.8 | 60 ± 1.14 | N/T | 2.6 | N/T | 26.6 ± 2.6 |
| 7 | 5.3 ± 0.6 | 31.3 ± 14.03 | 10.6 ± 0.12 | 7.2 | 2.9 | 4.85 ± 0.18 |
| 8 | 38.17 ± 0.7 | >100 | N/T | 2.6 | 2.95 | 4.8 ± 0.92 |
| 9 | 8 ± 0.5 | 11.4 ± 0.04 | 16.4 ± 1.25 | 1.4 | 1.3 | N/T |
| Positive control | ||||||
| Actinomycin D | 5.1 ± 0.1 | 8.8 ± 2.5 | 1.9 ± 0.865 | 1.7 | 4.72 | |
| Acetyl pepstatin | 8.5 ± 0.72 | |||||
N/T: Not tested compounds (inhibitory % < 60% for PR inhibition and <80% cytotoxic).