. Author manuscript; available in PMC: 2014 Nov 6.

Published in final edited form as: J Am Chem Soc. 2013 Oct 24;135(44):10.1021/ja408917n. doi: 10.1021/ja408917n

Table 2.

Experimental Aqueous Solubility at pH 6.5 (S) and Computed ClogP

Compd	S, µg/mL	ClogP	Compd	S, µg/mL	ClogP
4	10.8	3.09	nevirapine	167^a	2.65
10b	37.9	2.70	efavirenz	68.0	4.67
10h	43.8	3.14	etravirine	<< 1^b	5.22
			rilpivirine	0.02,^c 0.24^d	5.75

Ref. 35.

Ref. 36.

Ref. 5, pH 7.

Ref. 37, pH 7.4.