Table 1.
Effects of GABAA receptor positive modulators on the discriminative stimulus effects of methamphetamine (1 mg/kg). MAR indicates methamphetamine-appropriate responding, SEM indicates standard error of measurement. Response rates are expressed as responses per second. Asterisks indicate values different from methamphetamine alone (p<0.05).
| Compound | Test Dose (mg/kg) | Meth Dose (mg/kg) | N Test | N Not complete first fixed ratio | Methamphetamine-appropriate responding (%) | MAR SEM | Rate (res/sec | Rate SEM |
|---|---|---|---|---|---|---|---|---|
| Saline | 0 | 0 | 10 | 0 | 0 | 0 | 0.46 | 0.09 |
| Methamphetamine | 1 | 0 | 10 | 0 | 100.0 | 0 | 0.40 | 0.07 |
| Chlordiazepoxide | 1 | 1 | 10 | 0 | 90.0 | 10.0 | 0.66 | 0.13 |
| Chlordiazepoxide | 5 | 1 | 10 | 0 | 53.8 * | 15.8 | 0.54 | 0.12 |
| Chlordiazepoxide | 25 | 1 | 10 | 1 | 42.5 * | 14.8 | 0.32 | 0.05 |
| Pentobarbital | 5 | 1 | 10 | 0 | 80.0 | 13.3 | 0.64 | 0.09 |
| Pentobarbital | 10 | 1 | 10 | 2 | 63.6 * | 17.8 | 0.35 | 0.10 |