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. Author manuscript; available in PMC: 2014 Dec 1.
Published in final edited form as: J Neuroimmune Pharmacol. 2013 Nov 12;8(5):10.1007/s11481-013-9508-y. doi: 10.1007/s11481-013-9508-y

Fig. 2. Epigenetic changes to the OPRM1 promoter.<.

Fig. 2

br>DNMT activity increases upon the early stages of SIV infection, methylating the OPRM1 promoter at CpG island 1 and CpG island 2. This prevents the Sp1 transcription factor from initiating the gene, allowing the virus to remain latent in the lymphocytes in the presence of morphine.