Table 3.
Summary of Cox regression analysis of overall survival duration of P27 nuclear and cytoplasm expression
|
Parameter |
Univariate analysis |
Multivariate analysis |
||||
|---|---|---|---|---|---|---|
| P | HR | 95% CI | P | HR | 95% CI | |
| Gender |
|
|
|
|
|
|
| Male vs. female |
0.485 |
0.488 |
0.665-2.361 |
|
|
|
| Age |
|
|
|
|
|
|
| ≥50 vs. <50 years |
0.787 |
0.073 |
0.620-1.881 |
|
|
|
| Family tumor history |
|
|
|
|
|
|
| Yes vs. No |
0.349 |
0.877 |
0.000-28.401 |
|
|
|
| Smoking |
|
|
|
|
|
|
| Yes vs. No |
0.387 |
0.748 |
0.368-1.474 |
|
|
|
| Chemotherapy |
|
|
|
|
|
|
| Yes vs. No |
0.700 |
1.153 |
0.560-2.372 |
|
|
|
| Radiotherapy |
|
|
|
|
|
|
| Yes vs. No |
0.005 |
0.369 |
0.184-0.742 |
0.944 |
1.032 |
0.431-2.469 |
| T classification |
|
|
|
|
|
|
| T1-T2 vs. T3-T4 |
0.000 |
13.289 |
1.884-8.223 |
0.014 |
6.032 |
1.225-6.067 |
| N classification |
|
|
|
|
|
|
| N0-N1 vs. N2--N3 |
0.000 |
2.950 |
1.662.-5.237 |
0.240 |
1.379 |
0.720-3.700 |
| M classification |
|
|
|
|
|
|
| M0 vs. M1 |
0.000 |
35.042 |
5.031-24.906 |
0.001 |
10.438 |
1.803-11.112 |
| TNM Clinical stage |
|
|
|
|
|
|
| I-II vs. III-IV |
0.000 |
19.386 |
3.592-27.943 |
0.051 |
3.795 |
0.992-14.238 |
| P27 expression |
|
|
|
|
|
|
| High expression vs. low expression | 0.030 | 4.724 | 0.290-0.938 | 0.682 | 0.168 | 0.471-1.637 |