. 2013 Dec 20;20(1):99. doi: 10.1186/1423-0127-20-99

Table 6.

Novel approaches to circumvent chemoresistance by modulating unique miRNAs

Cancer type	miRNA targeted for inhibition	Type of resistance circumvented	Delivery system for modulation of miRNAs	Reference
B-cell lymphoma	miR-21 – oncomiR addiction	--	Antisense strategy	[119]
Cholangiocarcinomas	miR-21 & miR-200b	Gecitabine resistance mediated by PTEN-dependent activation of PI3K signaling	Transfection with miRNA-specific antisense oligonucleotides	[120]
Glioblastoma Multiforme (GBM)	miR-9 – indirectly promoting expression of the MDR transporter P-gp	P-gp-mediated resistance to temozolomide	- Mesenchymal stem cell-derived exosomes	[112]
Glioblastoma Multiforme (GBM)		P-gp-mediated resistance to temozolomide	- To deliver anti-miR-9 to temozolomide-resistant GBM to reduce P-gp expression for resistance reversal	[112]
GBM	miR-21	- Temozolomide	Transfection with anit-miR-21 oligonucleotide	[121]
GBM	miR-21	- Enhance apoptosis	Transfection with anit-miR-21 oligonucleotide	[121]
Lung cancer	miR-92b	Cisplatin resistance mediated by downregulation of the tumor suppressor gene PTEN	Transfection with anti-miR-92b oligonucleotide	[122]