Table 1.

Minimal combinations of reprogramming determinant genes obtained after the application of our method in five different biological examples for specific transition between attractors corresponding to cellular phenotypes

Example	Transitions	DEPFCs	Minimal combinations of reprogramming determinant genes
T-helper	Th2-Th1	4	GATA3, T-bet
EMT	Epithelial-Mesenchymal	12	SNAI1, ZEB2, MIR203
HL60	HL60-Neutrophil	1	IL1B, CASP1, IRF1
iHEP	Fibroblast-Hepatocyte	2	FOXA2:PPARGC1A,NR5A2:UCP2, HNF1A:PPARGC1A,HNF4A:NR5A2, NR5A2:PPARGC1A, FOXA2:HNF4A, HNF1A:UCP2, AGT:NR5A2,AGT:FOXA2,FOXA2:UCP2, AGT:HNF1A, HNF1A:HNF4A
iCM	Fibroblast-Cardiomyocyte	2	GATA4, MEF2C
iPSCS	Fibroblast-iPSCS	7	MYC:POU5F1:SOX2, POU5F1:SOX2:mir-107,MYB:POU5F1:SOX2, ATF3:POU5F1:SOX2,POU5F1:SOX2:TP53,

Genes in bold correspond with those whose perturbation are represented in Figure 5.

Alternative combinations of reprogramming determinant genes are separated by comma. Combinations of reprogramming determinants genes perturbed in Figure 6 are in bold.